Convenient synthesis of some new pyrazolo[5,1-c]triazines, isoxazolo[3,4-d] pyrimidine and pyridine derivatives containing benzofuran moiety

Abdou Osman Abdelhamid; Abdelgawad Ali Fahmi; Amna Ali Mohamed Alsheflo

doi:10.5155/eurjchem.3.2.129-137.579

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Published: Jun 30, 2012

DOI: https://doi.org/10.5155/eurjchem.3.2.129-137.579

Keywords:

Triazines, Pyridines, Pyrazoles, Isoxazoles, Hydrazones, Benzoimidazo[2, 1-c][1, 2, 4]triazine

Section

Research Article

Issue

Vol. 3 No. 2 (2012): June 2012

Dates

Received 2011-12-26
Accepted 2012-02-04
Published 2012-06-30

Abdou Osman Abdelhamid

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt

Abdelgawad Ali Fahmi

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt

Amna Ali Mohamed Alsheflo

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt

Abstract

Pyrazolo[5,1-c][1,2,4]triazine, [1,2,4]triazolo[3,4-c][1,2,4]triazine, benzo[4,5]-imidazo[2,1-c][1,2,4]triazine, isoxazole, isoxazolo[3,4-d]pyridazine, pyrazole, pyridine, substituted urea and phenyl carbamate derivatives containing benzofuran moiety were synthesized via reaction of sodium salt of 5-hydroxy-l-benzofuran-2-ylpropenone or 1-(benzofuran-2-yl)-3-(dimethylamino)prop-2-en-1-one with diazotized heterocyclic amines, hydroximoyl chlorides and active methylene compounds. The structures of all the newly synthesized compounds were confirmed by elemental analyses, spectral data, and alternative synthetic routes, whenever possible.

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Abdelhamid, A. O.; Fahmi, A. A.; Alsheflo, A. A. M. Convenient Synthesis of Some New pyrazolo[5,1-c]triazines, isoxazolo[3,4-D] Pyrimidine and Pyridine Derivatives Containing Benzofuran Moiety. Eur. J. Chem. 2012, 3, 129-137.

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References

[1]. Rao, D. R.; Raychaudhuri, S. P.; Verma, V. S. Int. J. Tropical Plant Dis. 1994, 12, 177-185.

[2]. Hinshaw, B. C; Lconoudakis, O.; Townsend, L. B. Abstracts 112d National Meeting of the American Chemical Society, D. C. Washington. Sept. No MEDI-15, 1971.

[3]. Ito, I. Japanese Patent 70301011971; Chem. Abstr. 1974, 22827, 1971.

[4]. Tseng, C. P. U. S. Pat. 1989, 4838925; Chem. Abstr. 1990, 112, 7508.

[5]. Sakane, K.; Kawabata, K.; Inamoto, Y. Eur. Pat. 1989, 332156; Chem. Abstr. 1990, 112, 216538.

[6]. Fujikawa, Y.; Suzuki, M.; Sakashita, M.; Tanaka, S.; Wakamatsu, M.; Miyasaka, S. Jpn. Kokai Tokkyo Koho JP 01, 221, 381 [89, 221, 381] (CI. C07D487/04) 1989; Chem. Abstr. 1990, 112, 158268j.

[7]. Tseng, S. S.; Brabander, J. H.; Epstein, W. J. U. S. Pat. 1990, 4963553; Chem. Abstr. 1991, 114, 228937.

[8]. Taylor, R. C.; Stauffer, F. H.; Tomezuk, B. E. U. S. Pat. 1992, 5114944; Chem. Abstr. 1992, 117, 90318.

[9]. Hibino, H.; Myamoto, Y.; Myajima, M.; Maeda, H. Jpn. Kokai Tokkyo Koho Jp 05, 213, 756 [93, 213, 756] (CI. A61K31/505); Chem. Abstr. 1993, 119, 256547p.

[10]. Allen, E. E.; Maccoss, M.; Chakravarty, P. K.; Patchett, A. A.; Greenlee, W. J.; Walsh, T. F. Eur. Pat. 1992, 490587; Chem. Abstr. 1992, 117, 151008.

[11]. Gatta, F.; Perotti, F.; Gradoni, L.; Gramiccia, M.; Orsini, S.; Palazzo, G.; Rossi, V. Eur. J. Med. Chem. 1990, 25, 419-424.
http://dx.doi.org/10.1016/0223-5234(90)90005-N

[12]. Ahmed, A. H.; Hozayen, W. H.; El-Gandour, A. H. H; Abdelhamid, A. O. J. Heterocycl. Chem. 2007, 44, 803-810.
http://dx.doi.org/10.1002/jhet.5570440408

[13]. Abdelhamid, A. O.; Sayed, A. R.; Zaki, Y. H. Phosphorus Sulfur Silicon Relat. Elem. 2007, 182, 1447-1457.
http://dx.doi.org/10.1080/10426500701242145

[14]. Abdelhamid, A. O.; Abdelaziz, H. M. Phosphorus Sulfur Silicon Relat. Elem. 2007, 182, 2791-2800.
http://dx.doi.org/10.1080/10426500701521548

[15]. Abdelhamid, A. O.; El-Ghandour, A. H.; El-Reedy, A. A. M. J. Chin. Chem. Soc. 2008, 55, 406-413.

[16]. Abdelhamid, A. O.; Fahmi, A. A.; Halim, K. N. M. Eur. J. Chem. 2011, 2(3), 317-323.
http://dx.doi.org/10.5155/eurjchem.2.3.317-323.420

[17]. Keshk, E. M. Heteroatom Chem. 2004, 15, 85-91.
http://dx.doi.org/10.1002/hc.10219

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